Nguva pfupi yadarika, Desulfovibrio Vulgaris (Desulfovibrio Vulgaris), acetic acid inogadzira bhakitiriya inonyatsoshanda, yakaburitswa online mujenari repasi rose reMicrobiology naGut Microbes (District 1). Bhakitiriya rine simba rinogadzira acetic acid, rinoderedza chirwere chechiropa chisina doro mumakonzo.

Kwete-doro fatty chiropa chirwere (NAFLD) ndiyo inowanzogara isingaperi chirwere chechiropa, uye iye zvino kuchine kushayikwa kwemishonga inoshanda yekurapa. Nhamba huru yezvidzidzo zvakaratidza kuti intestinal microbiota disorder chinhu chinokosha pathogenesis yekufutisa-based metabolic zvirwere. Naizvozvo, kunanga intestinal microbiota regulation inoonekwa seyakakosha nzira nyowani yekudzivirira uye kurapwa kwezvirwere zvemetabolism.

Polysaccharides imhando yemasikirwo macromolecular makomisheni akaparadzirwa zvakanyanya muTraditional Chinese mushonga. Nhamba huru yezvidzidzo zvakaratidza kuti chirimwa che polysaccharides chine mhedzisiro pakugadzirisa metabolism, asi iyo chaiyo nzira haina kunyatso kujeka. Chikwata chaHoukai Li chakaratidza muzvidzidzo zvakapfuura kuti astragalus membranaceus polysaccharides, iyo inonyanya kushanda chikamu cheastragalus membranaceus, inogona kuvandudza kufutisa uye NAFLD, uye yakacherekedza kudzora mhedzisiro yeASTRagalus membranaceus polysaccharides pamatumbo emudumbu uye metabolites kuburikidza nemetagenomic yakasanganiswa metabonomic yakasanganiswa. Iyo axis hypothesis ye "drug-intestinal microbiota - metabolite - host metabolism" yakarongwa kuvandudza NAFLD kuumbwa neAPS.

Kubva pane iyi fungidziro yesainzi, timu yekutsvagisa yakaongorora chaiwo mabhakitiriya emudumbu uye ane hukama metabolites anodzorwa neAPS kuburikidza neakawanda-omics musanganiswa zano, uye akaona kuti kuvandudzwa kweNAFLD neAPS hakungori nehunhu hwekutsamira kwemaruva, asi zvakare kunogona kupfumisa intestinal. mabhakitiriya (Desulfovibrio Vulgaris). Zvimwe zvidzidzo zvakasimbisa kuti bhakitiriya rakanga risiri mugadziri wechisikigo weH2S chete, asiwo aive nekwaniso yekugadzira acetic acid. Exogenous supplementation yebhakitiriya iri yakavandudza zvakanyanya hepatic steatosis, insulin senitivity uye kuwanda kwehuremu mumakonzo akadyiswa kudya kwemafuta akawanda. Kuburikidza nechiropa RNA SEQ kuongorora uye molecular biology kudzidza, zvakasimbiswa kuti kuvandudzwa kweNAFLD kwakabatana nekuvharidzirwa kwechiropa FASN uye CD36 protein expression. Ichi chidzidzo chakapa humbowo hutsva hwekutsanangura nzira yeAPS mukuvandudza NAFLD, uye yakapawo chirevo chekuongorora mashandisirwo eAPS mukugadzirisa maruva emukati nekuvandudza mametabolism nerubatsiro rwemultiomics tekinoroji.

Ongororo yezvikamu zveastragalus polysaccharide monosaccharide muchidzidzo ichi yakabatsirwa nechikwata chaProfessor Ding Kan kubva kuShanghai Institute of Materia Medica, Chinese Academy of Sciences, uye yakanangwa metabolomics uye dhizaini yezvidzidzo zvakatsigirwa zvakasimba nechikwata chaProfessor Jia Wei kubva kuChipatara cheChitanhatu cheVanhu chakabatana. kuenda kuShanghai Jiao Tong University. Ningning Zheng naWei Jia vanyori vanowirirana bepa. Hong Ying, chiremba wezvechiremba weboka raProfessor Li Houkai, ndiye munyori wekutanga webepa, uye Shanghai University yeTraditional Chinese Medicine ndiyo yekutanga kusaina bepa. Tsvagiridzo iyi yakatsigirwa neNational Natural Science Research Foundation yekuChina.